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ABD70 Anti-Fbxl16 Antibody

Anti-Fbxl16 Antibody detects level of Fbxl16 & has been published & validated for use in Fbxl16.

Anti-Fbxl16 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Apoptosis - Additional Gene Symbol: Fbxl16 UniProt Number: A2RT62
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ABD70
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABD70
      DescriptionAnti-Fbxl16 Antibody
      Alternate Names
      • F-box/LRR-repeat protein 16
      • F-box and leucine-rich repeat protein 16
      Background InformationFbxl16, also known as F-box/LRR repeat protein 16, F-box and leucine-rich repeat protein 16, and encoded by the gene Fbxl16, is the protein responsible for the substrate recognition of SCF. SCF is the SKP1-CUL1-F-box protein- type E3 ubiquitin ligase complex. The Skp1-Cul1-F-box protein (SCF) complex is one of the most well-characterized types of ubiquitin ligase E3 proteins, with the E3 activity of the complex being regulated in part at the level of complex formation. The complex has important roles in the ubiquitination of proteins involved in the cell cycle and also marks various other cellular proteins for destruction. Fbxl16 appears to be a novel E2F1-regulated gene whose expression can be up regulated when particular cell cycle proteins are disrupted, and thus Fbxl16 expression is often high in cancerous tumors.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Fbxl16 Antibody detects level of Fbxl16 & has been published & validated for use in Fbxl16.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Fbxl16 in human cerebral cortex and thalamus tissues.

      Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Fbxl16 in human ileum tissues.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Fbxl16 in NIH/3T3 cell lysates, which were untransfected, transfected with Myc-tagged Fbxl16, and transfected with a negative control siRNA, and not in NIH/3T3 cell lysate transfected with Fbxl16 siRNA (Prof. Ray De Shaies, California Institute of Technology, Pasadena.).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to mouse Fbxl16.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rat and Mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Fbxl16
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~52 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in serum starved HeLa cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected Fbxl16 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABD70 04053252958175