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ABN433 Anti-Corticotropin-Releasing Factor Receptor 2 Antibody

This Anti-Corticotropin-Releasing Factor Receptor 2 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Corticotropin-Releasing Factor Receptor 2.

Anti-Corticotropin-Releasing Factor Receptor 2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: CRHR2, CRF2R, CRH2R UniProt Number: Q13324
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ABN433
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN433
      ReplacesAB9420
      DescriptionAnti-Corticotropin-Releasing Factor Receptor 2 Antibody
      Alternate Names
      • Corticotropin-releasing factor receptor 2
      • CRF-R-2
      • CRF-R2
      • CRFR-2
      • Corticotropin-Releasing Factor Receptor 2
      • Corticotropin-releasing hormone receptor 2
      • CRH-R-2
      • CRH-R2
      Background InformationCorticotropin-Releasing Factor Receptor 2 (CRFR2) is a G-protein coupled receptor for CRH (Corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Ligand binding activates adenylate cyclase leading to an increase in cAMP levels and subsequent gene activation. CRFR2 binds Urocortin (UCN) with the highest affinity. CRFR2 is localized to the plasma membrane, and CRFR2 has numerous isoforms but their functional importance remains to be discovered. Latest research is focused upon antagonists of the receptors for CRF. Astressin2-B, which is specific for CRFR2 and Astressin B which binds both CRFR1 and CRFR2 are two recent peptide antagonists. The research hopes to develop treatments for many CRF-dependent diseases in the periphery such as irritable bowel syndrome and even perhaps various social behaviors such as anxiety and anti-social activities.
      References
      Product Information
      FormatAffinity Purified
      HS Code3002 15 90
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Corticotropin-Releasing Factor Receptor 2 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Corticotropin-Releasing Factor Receptor 2.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected Corticotropin-Releasing Factor Receptor 2 in 10 µg of human brain tissue lysate.
      Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Corticotropin-Releasing Factor Receptor 2 in human colon and Bowman's capsule epithelial cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Corticotropin-Releasing Factor Receptor 2 near the N-terminal.
      EpitopeNear N-terminal
      Concentration1.0 mg/mL
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rat, Primate, Hamster, Monkey, Mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CRHR2
      • CRF2R
      • CRH2R
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~49 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing from ~45-65 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human colon tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Corticotropin-Releasing Factor Receptor 2 in 10 µg of human colon tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN433 04053252981838

      Documentation

      Anti-Corticotropin-Releasing Factor Receptor 2 Antibody MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Corticotropin-Releasing Factor Receptor 2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Corticotropin-Releasing Factor Receptor 2 - Q2437454 Q2437454
      Anti-Corticotropin-Releasing Factor Receptor 2 - 3207646 3207646
      Anti-Corticotropin-Releasing Factor Receptor 2 - 3389899 3389899
      Anti-Corticotropin-Releasing Factor Receptor 2 -2686118 2686118
      Anti-Corticotropin-Releasing Factor Receptor 2 Polyclonal Antibody 3067511
      Anti-Corticotropin-Releasing Factor Receptor 2 Polyclonal Antibody 3537567