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MABS2239-25UL Anti-CXCL9 Antibody, clone 2A6.9.9

Anti-CXCL9, clone 2A6.9.9, Cat. No. MABS2239, is an Armenian hamster monoclonal antibody that detects C-X-C motif chemokine 9 (CXCL9) and is tested for use in Neutralizing and Western Blotting.

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MABS2239-25UL
25 µL  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABS2239-25UL
      DescriptionAnti-CXCL9 Antibody, clone 2A6.9.9
      Alternate Names
      • C-X-C motif chemokine 9
      • Gamma-interferon-induced monokine
      • Monokine induced by interferon-gamma
      • MIG
      • MuMI
      • Protein m119
      • Small-inducible cytokine B9
      Background InformationC-X-C motif chemokine 9 (UniProt: P18340; also known as Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, MIG, MuMIG, Protein m119, Small-inducible cytokine B9) is encoded by the Cxcl9 (also known as Scyb9) gene (Gene ID: 17329) in murine species. CXCL9 is a small cytokine of the CXC chemokine family that lacks the Glu-Leu-Arg (ELR) domain. It is synthesized with a signal peptide (aa 1-21), which is subsequently cleaved off to generate the mature form. It is induced in macrophages in response to interferon- g and participates in immune and inflammatory response. Its actions are mediated via CXC-chemokine receptor 3 (CXCR3). CXCL10 and CXCL11 that are structurally related to CXCL9 also serve as ligands for CXCR3 and contribute to its activation in CXCR3 expressing cells. Overexpression of CXCL9 is reported to reduced tumor progression and metastasis via the inhibition of angiogenesis. Conversely, CXCL9 can also act directly on tumor cells expressing the CXCR3 receptor to promote cell migration and epithelial mesenchymal transition.
      References
      Product Information
      FormatPurified
      PresentationPurified Armenian hamster monoclonal antibody IgG in PBS without preservatives.
      Quality LevelMQ200
      Applications
      ApplicationAnti-CXCL9, clone 2A6.9.9, Cat. No. MABS2239, is an Armenian hamster monoclonal antibody that detects C-X-C motif chemokine 9 (CXCL9) and is tested for use in Neutralizing and Western Blotting.
      Key Applications
      • Western Blotting
      • Neutralizing
      Application NotesTested Applications

      Neutralizing Analysis: A representative lot detected CXCL9 in Neutralizing applications (Christen, U., et. al. (2003). J Immunol. 171(12):6838-45; Tajfirouz, D., et. al. (2017). Virology. 506:7-13).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenRecombinant mouse C-X-C motif chemokine 9 (CXCL9).
      EpitopeUnknown
      Clone2A6.9.9
      Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostArmenian Hamster
      SpecificityClone 2A6 is an Armenian Hamster monoclonal antibody that detects murine CXCL9/MIG.
      IsotypeIgGκ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Cxcl9
      • Scyb9
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~14 kDa observed; 14.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting with murine recombinant CXCL9/MIG protein.

      Western Blotting Analysis (WB): A 1:500 dilution of this antibody detected recombinant murine CXCL9/MIG protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -10°C to -25°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS2239-25UL 04065266298475