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MABS1163 Anti-CSF-1R/CD115 Antibody clone FER216

Anti-CSF-1R/CD115 Antibody clone FER216 is an antibody against CSF-1R for use in Western Blotting.

Anti-CSF-1R/CD115 Antibody clone FER216 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: CSF1R, CSFR, FMS, HDLS UniProt Number: P07333
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MABS1163
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1163
      DescriptionAnti-CSF-1R/CD115 Antibody clone FER216
      Alternate Names
      • Macrophage colony-stimulating factor 1 receptor
      • CD115
      • CSF-1 receptor
      • CSF-1-R
      • CSF-1R
      • M-CSF-R
      • Proto-oncogene c-Fms
      Background InformationMacrophage colony-stimulating factor 1 receptor (EC 2.7.10.1; UniProt P07333; also known as CD115, CSF-1 receptor, CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms) is encoded by the CSF1R (also known as CSFR, FMS, HDLS) gene (Gene ID 1436) in human. CSF1R is a CSF1/PDGF family receptor tyrosine kinase that mediates macrophage colony stimulating factor 1 (M-CSF1) and IL-34 signaling by acting as the receptor for these two cytokines. CSF1R plays a key role in the differentiation, recruitment and activation of tissue macrophages. Tumor-associated macrophages (TAMs) have been associated with survival in classic Hodgkin lymphoma (cHL) and other lymphoma types. Hyperphosphorylated CSF1R is found in cHL tissue and highlights the importance of CSF1/CSF1R signaling in the recruitment of TAMs. CSF1R is initially produced with a signal peptide sequence (a.a. 1-19), the removal of which yields the mature type I single transmembrane protein with an extracellular region (a.a. 20-517), a transmembrane segment (a.a. a.a. 518-538), and a cytoplasmic region (a.a. 539-972) that contains the kinase domain (a.a. 582-910).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CSF-1R/CD115 Antibody clone FER216 is an antibody against CSF-1R for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected CSF-1R/CD115 in 10 µg of human tonsil tissue lysate.
      Biological Information
      ImmunogenHuman IgG1 Fc-tagged recombinant human CSF-1R/CD115 extracellular domain.
      EpitopeExtracellular domain.
      CloneFER216
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone FER216 reacts with the extracellular domain of human CSFR1, but not the extracellular domain of human FGFR1. Clone FER216 detected the ~100 kDa human CSFR1 in nomral tonsil and Hodgkin lymphoma (cHL) tissue extracts, as well as an additional ~150 kDa phosphorylated CSFR1 band in cHL tissue extracts (Martín-Moreno, A.M., et al. (2015). PLoS One. 2015 Jun 12;10(6):e0125203).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CSF1R
      • CSFR
      • FMS
      • HDLS
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~107 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human colon tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected CSF-1R/CD115 in 10 µg of human colon tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS1163 04055977314281

      Documentation

      Anti-CSF-1R/CD115 Antibody clone FER216 MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CSF-1R/CD115 Antibody clone FER216 Certificates of Analysis

      TitleLot Number
      Anti-CSF-1R/CD115, clone FER216 - 3174760 3174760
      Anti-CSF-1R/CD115, clone FER216 - 3280061 3280061
      Anti-CSF-1R/CD115, clone FER216 - 3862594 3862594
      Anti-CSF-1R/CD115, clone FER216 - 3906402 3906402
      Anti-CSF-1R/CD115, clone FER216 - 3991572 3991572
      Anti-CSF-1R/CD115, clone FER216 - 4023281 4023281
      Anti-CSF-1R/CD115, clone FER216 - 4061835 4061835
      Anti-CSF-1R/CD115, clone FER216 -2751108 2751108
      Anti-CSF-1R/CD115, clone FER216 -2762050 2762050
      Anti-CSF-1R/CD115, clone FER216 -Q2641929 Q2641929
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies