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ABE1438-25UL Anti-60S Ribosomal Protein L26

Anti-60S Ribosomal Protein L26 Antibody, Cat. No. ABE1438-25UL, is a highly specific rabbit polyclonal antibody, that targets 60S ribosomal protein L26 and has been tested in Western Blotting and Immunohistochemistry (Paraffin).

Anti-60S Ribosomal Protein L26 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Gene Symbol: RPL26 UniProt Number: P61254
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ABE1438-25UL
25 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1438-25UL
      DescriptionAnti-60S Ribosomal Protein L26
      Background Information60S ribosomal protein L26 (UniProt: P61254) is encoded by the RPL26 gene (Gene ID: 6154) in human. 60S ribosomal protein L26 belongs to the ribosomal protein L24P family and is found in all eukaryotes. It is primarily localized in the cytoplasm, but to a lesser extent it is also found in the nucleoplasm and nucleolus. It associates with the large 60S subunit of the ribosome and contains a KOW motif, a conserved RNA-binding motif present in many ribosomal proteins. 60S ribosomal protein L26 is shown to be involved in translation. Knockdown of RPL26 results in a significant decrease in synthesis of 28S rRNA (associated with 60S subunit). Overexpression of RPL26 is shown to enhance the binding of p53 mRNA to the ribosomes and increase p53 translation, which subsequently leads to cell-cycle arrest at G1 phase and can enhance radiation-stimulated apoptosis. Mutations in RPL26 gene are reported to cause congenital non-regenerative hypoplastic anemia that is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-60S Ribosomal Protein L26 Antibody, Cat. No. ABE1438-25UL, is a highly specific rabbit polyclonal antibody, that targets 60S ribosomal protein L26 and has been tested in Western Blotting and Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected 60S Ribosomal Protein L26 in human cerebral cortex, human pancreas, and human colon tissues.
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to the first 95 amino acids from human 60S ribosomal protein L26.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody detects 60S ribosomal protein L26 in human.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • RPL26
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight17 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Hek293 cell lysate.
      Western Blotting Analysis: A 1:500 dilution of this antibody detected 60S Ribosomal Protein L26 in 10 µg of  HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1438-25UL 04054839453755