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04-039 Anti-20S proteasome subunit α2 Antibody, clone MCP21

Anti-20S proteasome subunit α2 Antibody, clone MCP21 detects level of 20S proteasome subunit α2 & has been published & validated for use in IP, WB, IH.

Anti-20S proteasome subunit α2 Antibody, clone MCP21 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Protein Trafficking Research Sub-Category: Ubiquitin & Ubiquitin Metabolism Gene Symbol: PSMA2, PSC3, MU, HC3, PSC2, PMSA2 UniProt Number: P25787
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04-039
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, RbIP, WB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-039
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-20S proteasome subunit α2 Antibody, clone MCP21
      Alternate Names
      • HC3
      • proteasome subunit alpha type 2
      References
      Product Information
      FormatPurified
      Presentation100 µL concentration of 1mg/mL purified ascites in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
      Quality LevelMQ100
      Applications
      ApplicationAnti-20S proteasome subunit α2 Antibody, clone MCP21 detects level of 20S proteasome subunit α2 & has been published & validated for use in IP, WB, IH.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenHuman placenta derived proteasomes
      CloneMCP21
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes proteasome subunit alpha type 2.
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Human
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
      Gene Symbol
      • PSMA2
      • PSC3
      • MU
      • HC3
      • PSC2
      • PMSA2
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P25787 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
      SIZE: 234 amino acids; 25899 Da
      SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      PTM: Phosphorylated on tyrosine residues; which may be important for nuclear import (By similarity).
      SIMILARITY: SwissProt: P25787 ## Belongs to the peptidase T1A family.
      Molecular Weight26 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of shipment for up to 12 months.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      04-039 04053252335501

      Documentation

      Anti-20S proteasome subunit α2 Antibody, clone MCP21 MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-20S proteasome subunit α2 Antibody, clone MCP21 Certificates of Analysis

      TitleLot Number
      Anti-20S proteasome subunit a2, clone MCP21 (mouse monoclonal IgG1) - 2088974 2088974
      Anti-20S proteasome subunit a2, clone MCP21 (mouse monoclonal IgG1) - 2186337 2186337
      Anti-20S proteasome subunit alpha;2, clone MCP21 - 0611045418 0611045418
      Anti-20S proteasome subunit α2, clone MCP21 (mouse monoclonal IgG1) 2992335
      Anti-20S proteasome subunit α2, clone MCP21 - 3193312 3193312
      Anti-20S proteasome subunit α2, clone MCP21 - 3749998 3749998
      Anti-20S proteasome subunit α2, clone MCP21 - 3760205 3760205
      Anti-20S proteasome subunit α2, clone MCP21 - 4183442 4183442
      Anti-20S proteasome subunit α2, clone MCP21 -2596539 2596539
      Anti-20S proteasome subunit α2, clone MCP21 -2718242 2718242
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      References

      Reference overviewPub Med ID
      Impact of ageing on proteasome structure and function in human lymphocytes
      Carrard, Geraldine, et al
      Int J Biochem Cell Biol, 35:728-39 (2003)  2003

      		12672464 12672464
      Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells
      Zhong, G, et al
      J Exp Med, 191:1525-34 (2000)  2000

      		10790427 10790427
      Human proteasomes analysed with monoclonal antibodies
      Hendil, K B, et al
      Biochem J, 305 ( Pt 1):245-52 (1995)  1995

      		7826336 7826336