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208719 ALLN - CAS 110044-82-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
110044-82-1C₂₀H₃₇N₃O₄

Pricing & Availability

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208719-25MG
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      208719-5MG
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          Description
          OverviewCell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available.
          Catalogue Number208719
          Brand Family Calbiochem®
          SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
          References
          ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
          Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
          Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
          Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
          Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
          Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
          Product Information
          CAS number110044-82-1
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₀H₃₇N₃O₄
          Chemical formulaC₂₀H₃₇N₃O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
          Biological Information
          Primary TargetCalpain-1
          Primary Target K<sub>i</sub>190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Global Trade Item Number
          Catalogue Number GTIN
          208719-25MG 04055977202656
          208719-5MG 04055977202663