208719 Sigma-AldrichALLN - CAS 110044-82-1 - Calbiochem
ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
More>> ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Less<<Synonyms: LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
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Overview
Key Spec Table
CAS # | Empirical Formula |
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110044-82-1 | C₂₀H₃₇N₃O₄ |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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208719-25MG |
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Plastic ampoule | 25 mg |
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208719-5MG |
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Plastic ampoule | 5 mg |
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Description | |
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Overview | Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available. |
Catalogue Number | 208719 |
Brand Family | Calbiochem® |
Synonyms | LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V |
Product Information | |
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CAS number | 110044-82-1 |
ATP Competitive | N |
Form | White to off-white solid |
Hill Formula | C₂₀H₃₇N₃O₄ |
Chemical formula | C₂₀H₃₇N₃O₄ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
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Application | ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). |
Biological Information | |
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Primary Target | Calpain-1 |
Primary Target K<sub>i</sub> | 190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Peptide Sequence | N-Acetyl-Leu-Leu-Nle-CHO |
Global Trade Item Number | |
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Catalogue Number | GTIN |
208719-25MG | 04055977202656 |
208719-5MG | 04055977202663 |