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658395 AG 18 - CAS 118409-57-7 - Calbiochem

A broad-spectrum protein tyrosine kinase inhibitor.

AG 18 - CAS 118409-57-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810

Primary Target: epidermal growth factor receptor autophosphorylation
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118409-57-7C₁₀H₆N₂O₂

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      Description
      OverviewA broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.
      Catalogue Number658395
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
      References
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Kapas, S., et al. 1995. Biochem. J. 305, 433.
      Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
      Williams, J.A. 1994. Am. J. Physiol. 267, G401.
      Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.
      Product Information
      CAS number118409-57-7
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₀H₆N₂O₂
      Chemical formulaC₁₀H₆N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetepidermal growth factor receptor autophosphorylation
      Primary Target IC<sub>50</sub>40 µM against epidermal growth factor receptor autophosphorylation; 10 µM against GTPase activity of transducin
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      658395-5MG 04055977261547

      Documentation

      AG 18 - CAS 118409-57-7 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      AG 18 - CAS 118409-57-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      658395

      References

      Reference overview
      Jaleel, M., et al. 2004. Biochemistry 43, 8247.
      Kapas, S., et al. 1995. Biochem. J. 305, 433.
      Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
      Williams, J.A. 1994. Am. J. Physiol. 267, G401.
      Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-May-2011 RFH
      Synonymsα-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
      DescriptionA cell-permeable, reversible, substrate competitive protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to angiotensin II. Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. Also reported to inhibit guanylyl cyclase.
      FormYellow solid
      CAS number118409-57-7
      Chemical formulaC₁₀H₆N₂O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityAcetic acid, DMSO (100 mg/ml), or ethanol (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Kapas, S., et al. 1995. Biochem. J. 305, 433.
      Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
      Williams, J.A. 1994. Am. J. Physiol. 267, G401.
      Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.