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100065 2-APB - CAS 524-95-8 - Calbiochem

A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.

2-APB - CAS 524-95-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane

Primary Target: Ins(1,4,5)P3-induced Ca2+ release
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100065
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
524-95-8C₁₄H₁₆BNO

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      Description
      OverviewA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. Does not affect Ca2+ release from the ryanodine-sensitive Ca2+ store in rat leg skeletal muscle and heart. Inhibits spontaneous as well as the phasic contractions induced by uterotonic agents. Also reported to inhibit angiotensin II-induced contractions in aortic muscles.
      Catalogue Number100065
      Brand Family Calbiochem®
      Synonyms2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
      References
      ReferencesBrooke, R. T., et al. 2004. Lab. Invest. 84, 29.
      Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
      Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
      Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
      Maruyama, T., et al. 1997. J. Biochem. 122, 498.
      Product Information
      CAS number524-95-8
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₁₄H₁₆BNO
      Chemical formulaC₁₄H₁₆BNO
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIns(1,4,5)P3-induced Ca2+ release
      Primary Target IC<sub>50</sub>42 µM against Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations
      Purity≥97% by titration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSED6150000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      100065-100MG 07790788056766

      Documentation

      2-APB - CAS 524-95-8 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      2-APB - CAS 524-95-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      100065

      References

      Reference overview
      Brooke, R. T., et al. 2004. Lab. Invest. 84, 29.
      Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
      Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
      Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
      Maruyama, T., et al. 1997. J. Biochem. 122, 498.

      Citations

      Title
    • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-July-2009 RFH
      Synonyms2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
      DescriptionA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca2+ channels through a mechanism which may involve its binding to either the channel protein or an associated regulatory protein. Has no effect on the Ca2+ release from the ryanodine-sensitive Ca2+ store prepared from rat leg skeletal muscle and heart.
      FormWhite crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number524-95-8
      RTECSED6150000
      Chemical formulaC₁₄H₁₆BNO
      Structure formulaStructure formula
      Purity≥97% by titration
      SolubilityDMSO (20 mg/ml) and 95% Ethanol (25 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesBrooke, R. T., et al. 2004. Lab. Invest. 84, 29.
      Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
      Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
      Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
      Maruyama, T., et al. 1997. J. Biochem. 122, 498.
      Citation
    • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
      		•