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565783 β-Secretase Substrate VIII, Fluorogenic

β-Secretase Substrate VIII, Fluorogenic MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: JMV2236, Abz-VNL~DAE-EDDnp

565783
  
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      Overview

      Replacement Information
      Description
      OverviewAn internally quenched fluorogenic peptide substrate designed from Swedish mutated β-APP (β-amyloid precursor protein) sequence that specifically detects the activity of BACE1 (β-secretase 1) and BACE2, but not that of cathepsin-D, ADAM-10, TACE, PS1, or PS2. Cleavage occurs between Leu-Asp residues, which results in fluorescence enhancement. Also useful for screening of inhibitors for BACE1 & BACE2.
      Catalogue Number565783
      Brand Family Calbiochem®
      SynonymsJMV2236, Abz-VNL~DAE-EDDnp
      References
      ReferencesAndrau, D., et al. 2003. J. Biol. Chem. 278, 25859.
      Product Information
      FormLyophilized yellow solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₂H₅₈N₁₂O₁₆
      Chemical formulaC₄₂H₅₈N₁₂O₁₆
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Peptide SequenceAbz-Val-Asn-Leu~Asp-Ala-Glu-EDDnp
      Abz = 2-Aminobenzoyl; EDDnp = N-(2,4-dinitrophenyl)ethylenediamine
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565783 0

      Documentation

      β-Secretase Substrate VIII, Fluorogenic Certificates of Analysis

      TitleLot Number
      565783

      References

      Reference overview
      Andrau, D., et al. 2003. J. Biol. Chem. 278, 25859.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2008 JSW
      SynonymsJMV2236, Abz-VNL~DAE-EDDnp
      DescriptionAn internally quenched fluorogenic peptide substrate designed from the Swedish mutant β-APP (β-amyloid precursor protein) sequence that specifically detects the activity of BACE1 (β-secretase 1) and BACE2, but not that of cathepsin-D, ADAM10, TACE, PS1, or PS2. Cleavage occurs at the Leu-Asp bond resulting in enhanced fluorescence. Also useful for screening of inhibitors for BACE1 & BACE2. Excitation max: ~320 nm; emission max: ~420 nm.
      FormLyophilized yellow solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₂H₅₈N₁₂O₁₆
      Peptide SequenceAbz-Val-Asn-Leu~Asp-Ala-Glu-EDDnp
      Abz = 2-Aminobenzoyl; EDDnp = N-(2,4-dinitrophenyl)ethylenediamine
      Purity≥98% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAndrau, D., et al. 2003. J. Biol. Chem. 278, 25859.