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23-027M b-catenin Protein, activated, 250 µg

Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

Key Applications: Enzyme Assays
23-027M
250 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Key ApplicationsSpeciesCascade Component
Enzyme AssaysHuman Substrate
Description
Catalogue Number23-027M
Brand Family Upstate
Trade Name
  • Upstate
Descriptionb-catenin Protein, activated, 250 µg
OverviewAXIS Axon Isolation Devices - culture dish mounted, 150 µm long channels, 5 devices
Alternate Names
  • Catenin beta-1
Background Informationβ-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActivated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.
Key Applications
  • Enzyme Assays
Biological Information
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Cascade ComponentSubstrate
Entrez Gene Number
Purification MethodPurified using immobilized metal affinity chromatography.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size250 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
23-027M 04053252294433

Documentation

Related Products & Applications

Alternative Packsize

Catalogue Number Description
23-027 b-catenin Protein, activated, 10 µg

Product Families

Ubiquitin Proteasome System: Enzymes and Substrates

Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
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Categories

Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitination Substrates
Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Ubiquitination Substrates