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14-658 WNK3 Protein, active, 10 µg

Active, N-terminal 6His-tagged, recombinant, human WNK3, amino acids 1-434, for use in Kinase Assays.

WNK3 Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-658
10 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-658
Brand Family Upstate
Trade Name
  • Upstate
DescriptionWNK3 Protein, active, 10 µg
OverviewN-terminal 6His-tagged, recombinant, human WNK3, amino acids 1-434
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human WNK3, amino acids 1-434, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed by baculovirus in Sf21 cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
Entrez Gene Number
Entrez Gene SummaryMembers of the 'with no lysine' (WNK) kinase family, such as WNK3, are serine-threonine protein kinases that lack the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. Instead, these kinases have a conserved lysine in subdomain I that is thought to provide this function (Holden et al., 2004 [PubMed 15194194]).[supplied by OMIM]
Gene Symbol
  • WNK3
  • KIAA1566
  • PRKWNK3
Protein TargetWNK3
Purification MethodNi2+/NTA-agarose
Target Sub-FamilySTE
UniProt Number
UniProt SummaryCOFACTOR: Magnesium (By similarity).
SIZE: 1743 amino acids; 191789 Da
TISSUE SPECIFICITY: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen.
SIMILARITY: SwissProt: Q9BYP7 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. & Contains 1 protein kinase domain.
Molecular Weight53.1kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of MBP (#13-104).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-658 04053252509186

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Alternative Packsize

Catalogue Number Description
14-658M WNK3 Protein, active, 250 µg

Product Families

Kinase & Phosphatase Products

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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases