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679130 Vitamin E Succinate

Vitamin E Succinate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Tocopheryl Succinate, VES

Primary Target: PKC activity
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4345-03-3C₃₃H₅₄O₅
Description
Overview

This product has been discontinued.





Enhances the immune response and induces cellular differentiation and/or growth inhibition. VES has been shown to modulate adenylate cyclase and cAMP-dependent proteins, inhibit protein kinase C activity, bind to a cellular vitamin E binding protein, suppress c-myc and c-H-ras oncogene expression, and regulate TGF-β protein production. Also shown to induce apoptosis in RL cells. Exhibits antioxidant properties.
Catalogue Number679130
Brand Family Calbiochem®
Synonymsα-Tocopheryl Succinate, VES
References
ReferencesTurley, J.M., et al. 1995. Cell Growth Differentiation 6, 655.
Fariss, M.W., et al. 1994. Cancer Res. 54, 3346.
Cohrs, R.J., et al. 1991. Int. J. Dev. Neurosci. 9, 187.
Sahu, S.N., and Prasad, K.N. 1988. Cancer 62, 949.
Product Information
CAS number4345-03-3
FormWhite to yellow solid
Hill FormulaC₃₃H₅₄O₅
Chemical formulaC₃₃H₅₄O₅
Applications
Biological Information
Biological activityPotency: ≥960 mg/g
Primary TargetPKC activity
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEJ9984000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
679130 0

Documentation

Vitamin E Succinate Certificates of Analysis

TitleLot Number
679130

References

Reference overview
Turley, J.M., et al. 1995. Cell Growth Differentiation 6, 655.
Fariss, M.W., et al. 1994. Cancer Res. 54, 3346.
Cohrs, R.J., et al. 1991. Int. J. Dev. Neurosci. 9, 187.
Sahu, S.N., and Prasad, K.N. 1988. Cancer 62, 949.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2010 RFH
Synonymsα-Tocopheryl Succinate, VES
DescriptionEnhances the immune response and induces cellular differentiation and/or growth inhibition. Potent and cell-permeable inhibitor of neuroblastoma cells, murine melanoma cells, avian lymphoid cells, human HL-60 promyelocytic leukemia cells, and several human breast carcinoma cell lines. VES has been shown to modulate adenylate cyclase and cAMP-dependent protein, inhibit protein kinase C activity, bind to cellular vitamin E binding protein, suppress c-myc and c-H-ras oncogene expression, and regulate TGFβ protein production. Also shown to induce apoptosis in RL cells. Prevents oxidative damage.
FormWhite to yellow solid
CAS number4345-03-3
RTECSEJ9984000
Chemical formulaC₃₃H₅₄O₅
Biological activityPotency: ≥960 mg/g
SolubilityChloroform (50 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 9495
ReferencesTurley, J.M., et al. 1995. Cell Growth Differentiation 6, 655.
Fariss, M.W., et al. 1994. Cancer Res. 54, 3346.
Cohrs, R.J., et al. 1991. Int. J. Dev. Neurosci. 9, 187.
Sahu, S.N., and Prasad, K.N. 1988. Cancer 62, 949.