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676377 Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem

A cyclododecadepsi-peptide ionophore antibiotic.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: NGF-induced neuronal differentiation
676377
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2001-95-8C₅₄H₉₀N₆O₁₈
Description
OverviewA cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K+ conductivity in cell membranes at concentrations as low as 10-8 M. Often used in membrane electrode systems for determining K+ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
Catalogue Number676377
Brand Family Calbiochem®
References
ReferencesHarada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
Pape, P.C., et al. 1992. J. Physiol. 449, 219.
Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
Lerner, A., et al. 1982. FEBS Lett. 146, 9.
Product Information
CAS number2001-95-8
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₅₄H₉₀N₆O₁₈
Chemical formulaC₅₄H₉₀N₆O₁₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary TargetNGF-induced neuronal differentiation
Purity≥93% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYV9468000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
676377 0

Documentation

Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem Certificates of Analysis

TitleLot Number
676377

References

Reference overview
Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
Pape, P.C., et al. 1992. J. Physiol. 449, 219.
Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
Lerner, A., et al. 1982. FEBS Lett. 146, 9.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2008 RFH
DescriptionA cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb+ >K+ >Cs+ >Ag+ >NH4+ >Na+ >Li+). Induces K+ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K+ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K+ concentration. Useful in studies of K+ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
FormWhite crystalline solid
CAS number2001-95-8
RTECSYV9468000
Chemical formulaC₅₄H₉₀N₆O₁₈
Structure formulaStructure formula
Purity≥93% by HPLC
SolubilityAcetic acid, CHCl₃, DMSO, or ether
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Toxicity Highly Toxic
Merck USA index14, 9910
ReferencesHarada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
Pape, P.C., et al. 1992. J. Physiol. 449, 219.
Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
Lerner, A., et al. 1982. FEBS Lett. 146, 9.

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Categories

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Mitochondrial Function Inhibitors