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676485 VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem

The VEGFR2 Kinase Inhibitor II, also referenced under CAS 288144-20-7, controls the biological activity of VEGFR2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII

Primary Target: VEGF-R2 (KDR/Flk-1)
676485
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
288144-20-7C₁₇H₁₅BrN₂O
Description
Overview

This product has been discontinued.



A membrane permeant and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 µM for p60c-src, and 13.3 µM for FGF-R1]. The inhibition is suggested to be competitive with respect to ATP. Does not inhibit EGF-R kinase activity (IC50 > 100 µM).
Catalogue Number676485
Brand Family Calbiochem®
Synonyms(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII
References
ReferencesSun, L., et al. 2000. J. Med. Chem. 43, 2655.
Product Information
CAS number288144-20-7
ATP CompetitiveY
FormBrown solid
Hill FormulaC₁₇H₁₅BrN₂O
Chemical formulaC₁₇H₁₅BrN₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetVEGF-R2 (KDR/Flk-1)
Primary Target IC<sub>50</sub>70 nM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
676485 0

Documentation

VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem Certificates of Analysis

TitleLot Number
676485

References

Reference overview
Sun, L., et al. 2000. J. Med. Chem. 43, 2655.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-January-2010 RFH
Synonyms(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII
DescriptionA cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 µM for p60c-src, and 13.3 µM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC50 = 110 nM) and PDGF-induced (IC50 = 2.01 µM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC50 >100 µM).
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number288144-20-7
Chemical formulaC₁₇H₁₅BrN₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSun, L., et al. 2000. J. Med. Chem. 43, 2655.