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532910 TrxR Inhibitor, D9 - Calbiochem

TrxR Inhibitor, D9, is a cell permeable, highly stable phosphinyl gold (I) acetylide complex that acts as a highly potent inhibitor of thioredoxin reductase (TrxR; EC₅₀ = 2.8 nM).

TrxR Inhibitor, D9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Thioredoxin inhibitor, D9

Primary Target: TrxR
532910
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₅H₂₀AuOPS

Products

Catalogue NumberPackaging Qty/Pack
5.32910.0001 Glass bottle 10 mg
Description
OverviewA cell permeable, highly stable phosphinyl gold (I) acetylide complex that acts as a highly potent inhibitor of thioredoxin reductase (TrxR; EC50 = 2.8 nM). Acts by blocking the redox-active selenenylsulfide motif of TrxR in an irreversible manner. Displays high selectivity over glutathione reductase (EC50 > 1000 nM). Selectively reduces the viability and proliferation of MCF-7 and HT-29 cancer cells (IC50 = 30 and 100 nM, respectively) without affecting normal cells. Suppresses the growth of MCF-7 xenografts in BALB/c nude mice (5 mg/kg; i.v.,given on alternate days for 15 days).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number532910
Brand Family Calbiochem®
SynonymsThioredoxin inhibitor, D9
References
ReferencesZhang, D., et al. 2014. J. Med. Chem. 57, 8132.
Product Information
FormWhite solid
Hill FormulaC₂₅H₂₀AuOPS
Chemical formulaC₂₅H₂₀AuOPS
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetTrxR
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.32910.0001 04055977281941

Documentation

TrxR Inhibitor, D9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Zhang, D., et al. 2014. J. Med. Chem. 57, 8132.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-November-2015 JSW
SynonymsThioredoxin inhibitor, D9
DescriptionA cell permeable, highly stable phosphinyl gold (I) acetylide complex that acts as a highly potent inhibitor of thioredoxin reductase (TrxR; EC50 = 2.8 nM). Acts by blocking the redox-active selenenylsulfide motif of TrxR in an irreversible manner. Displays high selectivity over glutathione reductase (EC50 > 1000 nM). Selectively reduces the viability and proliferation of MCF-7 and HT-29 cancer cells (IC50 = 30 and 100 nM, respectively) without affecting normal cells. Suppresses the growth of MCF-7 xenografts in BALB/c nude mice (5 mg/kg; i.v.,given on alternate days for 15 days).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₅H₂₀AuOPS
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesZhang, D., et al. 2014. J. Med. Chem. 57, 8132.