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504793 Tamsulosin Hydrochloride - CAS 106463-17-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (R)-5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide hydrochloride, Tamsulosin, α₁-Adrenoceptor Antagonist, Tamsulosin Hydrochloride

Primary Target: →1A adrenoceptor
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
106463-17-6C₂₀H₂₈N₂O₅S • HCl
Description
Overview

This product has been discontinued.



A selective α1A adrenoceptor antagonist that has preferential selectivity for the α1A adrenoceptor in the prostate versus the α1B adrenoceptor in the blood vessels (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Used for treatment of difficult urination, a common symptom of enlarged prostate. Has negligible effect on arterial blood pressure in vivo.
Catalogue Number504793
Brand Family Calbiochem®
Synonyms(R)-5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide hydrochloride, Tamsulosin, α₁-Adrenoceptor Antagonist, Tamsulosin Hydrochloride
References
ReferencesGarcia-Sainz, J., et al. 1995. Eur. J. Pharmacol. 289, 1.
Taguchi, K., et al. J. Pharmacol. Exp. Ther. 280, 1.
Ohtake, A., et al. 2005. J. Pharm. Pharmacol. 58, 345.
Roehrborn, G., et al. 2008. J. Urol. 179, 616.
Product Information
CAS number106463-17-6
FormWhite to beige powder
Hill FormulaC₂₀H₂₈N₂O₅S • HCl
Chemical formulaC₂₀H₂₈N₂O₅S • HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target→1A adrenoceptor
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +15°C to +30°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
504793 0

Documentation

Tamsulosin Hydrochloride - CAS 106463-17-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Garcia-Sainz, J., et al. 1995. Eur. J. Pharmacol. 289, 1.
Taguchi, K., et al. J. Pharmacol. Exp. Ther. 280, 1.
Ohtake, A., et al. 2005. J. Pharm. Pharmacol. 58, 345.
Roehrborn, G., et al. 2008. J. Urol. 179, 616.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-February-2020 JSW
Synonyms(R)-5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide hydrochloride, Tamsulosin, α₁-Adrenoceptor Antagonist, Tamsulosin Hydrochloride
DescriptionA selective α1A adrenoceptor antagonist that has preferential selectivity for the α1A adrenoceptor in the prostate versus the α1B adrenoceptor in the blood vessels (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Used for treatment of difficult urination, a common symptom of enlarged prostate. Has negligible effect on arterial blood pressure in vivo.
FormWhite to beige powder
CAS number106463-17-6
Chemical formulaC₂₀H₂₈N₂O₅S • HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from moisture
Protect from light
+15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGarcia-Sainz, J., et al. 1995. Eur. J. Pharmacol. 289, 1.
Taguchi, K., et al. J. Pharmacol. Exp. Ther. 280, 1.
Ohtake, A., et al. 2005. J. Pharm. Pharmacol. 58, 345.
Roehrborn, G., et al. 2008. J. Urol. 179, 616.