Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

GF346 TGF-β1,
Human Recombinant Animal Free

TGF-β1,
Human Recombinant Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P01137
GF346
10µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

SourcePurity
CHO cellsProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Description
Catalogue NumberGF346
DescriptionTGF-β1,
Human Recombinant Animal Free
Alternate Names
  • TGFb1
  • TGFbI
  • TGFB
  • Transforming Growth Factor-β1
Background InformationThe three mammalian isoforms of TGF-β (TGF-β1, TGF-β2, TGF-β3) signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF- isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors.

Recombinant human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
References
Product Information
PresentationProduct is presented without additives and is filtered through a 0.2 micron filter before lyophilization
Quality LevelMQ100
Applications
Biological Information
PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
SourceCHO cells
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceDetermined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
Packaging Information
Material Size10µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
GF346 04053252979057

Documentation

TGF-β1,
Human Recombinant Animal Free SDS

Title

Safety Data Sheet (SDS) 

TGF-β1,
Human Recombinant Animal Free Certificates of Analysis

TitleLot Number
TGF-β1, Human Recombinant Animal Free 3075618
TGF-β1, Human Recombinant Animal Free 2653155
TGF-β1, Human Recombinant Animal Free 3023623
TGF-β1, Human Recombinant Animal Free 2898459
TGF-β1, Human Recombinant Animal Free 2582331
TGF-β1, Human Recombinant Animal Free 2620658
TGF-β1, Human Recombinant Animal Free 2886936
TGF-β1, Human Recombinant Animal Free 3026595
TGF-β1, Human Recombinant Animal Free 2708982
TGF-β1, Human Recombinant Animal Free 2939374
Show more

Related Products & Applications

Product Families

Cytokines and Growth Factors

EMD Millipore offers a comprehensive range of highly purified bioactive cytokines and growth factors for use in human, mouse, and rat cell culture, stem cell differentiation and ELISA studies.
Learn More >>

Categories

Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors