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572632 SU5614 - CAS 186611-56-3 - Calbiochem

SU5614 - CAS 186611-56-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone, VEGFR Tyrosine Kinase Inhibitor VII, VEGFR2 Kinase Inhibitor IX

Primary Target: VEGF Flk-1
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Overview

Key Spec Table

CAS #Empirical Formula
186611-56-3C₁₅H₁₃N₂OCl
Description
Overview

This product has been discontinued.



A potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC50 = 1.2 µM) and PDGF (IC50 = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC50 ≤ 680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.
Catalogue Number572632
Brand Family Calbiochem®
Synonyms5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone, VEGFR Tyrosine Kinase Inhibitor VII, VEGFR2 Kinase Inhibitor IX
References
ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
Product Information
CAS number186611-56-3
ATP CompetitiveY
DeclarationNot available for sale in the United States.
FormOrange-red solid
Hill FormulaC₁₅H₁₃N₂OCl
Chemical formulaC₁₅H₁₃N₂OCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetVEGF Flk-1
Primary Target IC<sub>50</sub>1.2 µM, 2.9 µM against VEGF (Flk-1) and PDGF receptor tyrosine kinases, respectively; ≤680 nM against the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
572632 0