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570250 STO-609 - CAS 52029-86-4 - Calbiochem

A cell-permeable and reversible naphthoyl fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/CaM-KK.

STO-609 - CAS 52029-86-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7H-Benz[de]benzimidazo[2,1-a]isoquinoline-7-one-3-carboxylic Acid, Acetate, 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid, Acetate

Primary Target: CaM-KKα
570250
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
52029-86-4C₁₉H₁₀N₂O₃ • CH₃CO₂H
Description
OverviewA cell-permeable and reversible naphthoyl fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) [IC50 = 120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively]. Binds to the catalytic domain of CaM-KK, and inhibits autophosphorylation. Does not significantly affect the activities of CaM-KII, MLCK (IC50 = ~10 µg/ml), CaM-KI, CaM-KIV, PKA, PKC, and p42 MAP kinase (IC50 >10 µg/ml). Has also been reported to inhibit phosphorylation of AMP-activated protein kinase (AMPK).
Catalogue Number570250
Brand Family Calbiochem®
Synonyms7H-Benz[de]benzimidazo[2,1-a]isoquinoline-7-one-3-carboxylic Acid, Acetate, 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid, Acetate
References
ReferencesLevine, Y., et al. 2007. J. Biol. Chem. 282, 20351.
Tokumitsu, H., et al. 2003. J. Biol. Chem. 278, 10908.
Tokumitsu, H., et al. 2002. J. Biol. Chem. 277, 15813.
Product Information
CAS number52029-86-4
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₉H₁₀N₂O₃ • CH₃CO₂H
Chemical formulaC₁₉H₁₀N₂O₃ • CH₃CO₂H
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCaM-KKα
Primary Target IC<sub>50</sub>120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
570250 0

Documentation

STO-609 - CAS 52029-86-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

STO-609 - CAS 52029-86-4 - Calbiochem Certificates of Analysis

TitleLot Number
570250

References

Reference overview
Levine, Y., et al. 2007. J. Biol. Chem. 282, 20351.
Tokumitsu, H., et al. 2003. J. Biol. Chem. 278, 10908.
Tokumitsu, H., et al. 2002. J. Biol. Chem. 277, 15813.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-November-2009 RFH
Synonyms7H-Benz[de]benzimidazo[2,1-a]isoquinoline-7-one-3-carboxylic Acid, Acetate, 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid, Acetate
DescriptionA cell-permeable and reversible napthoyl-fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) (IC50 = 120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively). Reported to bind to the catalytic domain of CaM-KK, and inhibit autophosphorylation. Does not significantly affect the activities of CaM-KII, MLCK (IC50 ~10 µg/ml), CaM-KI, CaM-KIV, PKA, PKC and p42 MAP kinase (IC50 >10 µg/ml). Has also been reported to inhibit phosphorylation of AMP-activated protein kinase (AMPK).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number52029-86-4
Chemical formulaC₁₉H₁₀N₂O₃ • CH₃CO₂H
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or 100 mM NaOH (20 mg/ml). May require warming to acheive complete solubilization in DMSO.
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLevine, Y., et al. 2007. J. Biol. Chem. 282, 20351.
Tokumitsu, H., et al. 2003. J. Biol. Chem. 278, 10908.
Tokumitsu, H., et al. 2002. J. Biol. Chem. 277, 15813.