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573108 STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem

573108
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Overview

Key Spec Table

CAS #Empirical Formula
285986-31-4C₁₆H₁₁N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
573108-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
Catalogue Number573108
Brand Family Calbiochem®
SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
References
ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.
Product Information
CAS number285986-31-4
FormWhite solid
Hill FormulaC₁₆H₁₁N₃O₃
Chemical formulaC₁₆H₁₁N₃O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSTAT5 Inhibitor, CAS 285986-31-4, is a cell-permeable compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity).
Biological Information
Purity≥97% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
573108-10MG 04055977265941