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48-602MAG
Buffer Detection Kit for Magnetic Beads
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553502
Sigma-AldrichRac1 Inhibitor - CAS 1177865-17-6 - Calbiochem
Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC₅₀ ~50 µM).
More>>Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC₅₀ ~50 µM). Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
Catalogue Number
553502
Brand Family
Calbiochem®
Synonyms
NSC23766
References
References
Dwivedi, S., et al. 2010. J. Translational Med.8, 128. Desire, L., et al. 2005. J. Biol. Chem.280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA101, 7618.
Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Certificates of Analysis
Title
Lot Number
553502
References
Reference overview
Dwivedi, S., et al. 2010. J. Translational Med.8, 128. Desire, L., et al. 2005. J. Biol. Chem.280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA101, 7618.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
28-February-2012 RFH
Synonyms
NSC23766
Description
A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
Form
Lyophilized
Intert gas (Yes/No)
Packaged under inert gas
CAS number
1177865-17-6
Chemical formula
C₂₄H₃₈Cl₃N₇
Structure formula
Purity
≥93% by HPLC
Solubility
H₂O (5 mg/ml)
Storage
Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Carcinogenic / Teratogenic
References
Dwivedi, S., et al. 2010. J. Translational Med.8, 128. Desire, L., et al. 2005. J. Biol. Chem.280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA101, 7618.
