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532757 RIPK2 Inhibitor, OD36 - CAS 1638644-62-8 - Calbiochem

A cell permeable, highly potent, selective, and ATP-competitive inhibitor of receptor-interacting protein 2 (RIPK2, IC₅₀ = 5.3 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: RIPK2 inhibitor, RIP kinase inhibitor

Primary Target: RIPK2
532757
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1638644-62-8C₁₆H₁₅ClN₄O₂

Products

Catalogue NumberPackaging Qty/Pack
5.32757.0001 Glass bottle 5 mg
Description
OverviewA cell permeable, pyrazolopyridine containing macrocycle derivative that acts as a highly potent, selective, ATP-competitive and reversible inhibitor of receptor-interacting protein 2 (RIPK2, IC50 = 5.3 nM). Shown to minimally affect the activity of 366 other protein kinases. At higher concentrations (100 nM), inhibits ALK-2, salt-inducible kinase 2 (SIK2), activin receptor type-2B (ACVR2B), and activin A receptor type II-like 1 (ACVRL1) by ~80%. Blocks RIPK2 autophosphorylation and downstream NF-κB and MAP kinase signaling induced by muramyl dipeptide (MDP), and reduces MDP-induced cellular infiltration of neutrophils and lymphocytes in an in vivo peritonitis model (6.25 mg/kg, i.p.).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number532757
Brand Family Calbiochem®
SynonymsRIPK2 inhibitor, RIP kinase inhibitor
References
ReferencesTigno-Aranjuez, J.T., et al. 2014. J. Biol. Chem. 289, 29651.
Product Information
CAS number1638644-62-8
FormLight beige powder
Hill FormulaC₁₆H₁₅ClN₄O₂
Chemical formulaC₁₆H₁₅ClN₄O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetRIPK2
Primary Target IC<sub>50</sub>5.3 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.32757.0001 04055977281880

Documentation

RIPK2 Inhibitor, OD36 - CAS 1638644-62-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Tigno-Aranjuez, J.T., et al. 2014. J. Biol. Chem. 289, 29651.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-July-2015 JSW
SynonymsRIPK2 inhibitor, RIP kinase inhibitor
DescriptionA cell permeable, pyrazolopyrinide containing macrocycle derivative that acts as a highly potent, selective, and ATP-competitive inhibitor of receptor-interacting protein 2 (RIPK2, IC50 = 5.3 nM). At ~20-fold higher concentration inhibits (~80% inhibition at 100 nM) the activity of ALK-2, salt-inducible kinase 2 (SIK2), activin receptor type-2B (ACVR2B), and activin A receptor type II-like 1(ACVRL1), but does not affect the activity of 366 other protein kinases. Blocks RIPK2 autophosphorylation and downstream NF-κB and MAP kinase signaling induced by muramyl dipeptide (MDP) and reduces MDP-induced cellular infiltration of neutrophils and lymphocytes in an in vivo peritonitis model (6.25 mg/kg).
FormLight beige powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1638644-62-8
Chemical formulaC₁₆H₁₅ClN₄O₂
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTigno-Aranjuez, J.T., et al. 2014. J. Biol. Chem. 289, 29651.