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5291 Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Aerosporin

5291
  
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Overview

Replacement Information

Key Spec Table

CAS #
1405-20-5
Description
OverviewAn antibiotic that inhibits phospholipid-sensitive Ca2+-dependent protein kinases. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.
Catalogue Number5291
Brand Family Calbiochem®
SynonymsAerosporin
References
ReferencesLucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
Marra, M.N., et al. 1990. J. Immunol. 144, 662.
Product Information
CAS number1405-20-5
FormWhite to off-white solid
Quality LevelMQ200
Applications
Biological Information
Biological activityPotency: ≥7500 IU/mg
Primary TargetPhospholipid sensitive Ca2+ dependent protein kinases
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSTR1150000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5291 0

Documentation

Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem Certificates of Analysis

TitleLot Number
5291

References

Reference overview
Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
Marra, M.N., et al. 1990. J. Immunol. 144, 662.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-January-2011 JSW
SynonymsAerosporin
DescriptionAn antibiotic that inhibits phospholipid sensitive Ca2+-dependent protein kinase. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate.
FormWhite to off-white solid
CAS number1405-20-5
RTECSTR1150000
Biological activityPotency: ≥7500 IU/mg
SolubilityH₂O (25 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
Toxicity Harmful
Merck USA index14, 7573
ReferencesLucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
Marra, M.N., et al. 1990. J. Immunol. 144, 662.