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524714 Phosphodiesterase V Inhibitor II

Phosphodiesterase V Inhibitor II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PDE V Inhibitor II

524714
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.

Please refer to our complete listing of phosphodiesterase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





A cell-permeable tetrahydro-β-carboline-hydantoin compound that acts as a potent and highly selective phosphodiesterase V inhibitor (IC50 = 5 nM for bovine aorta PDE V; IC50 > 10 µM for human recombinant PDE I & III, and for bovine aorta PDE II & IV]. Shown to increase intracellular cGMP levels in ANF-treated RSMC (EC50 = 1 µM) and significantly lower blood pressure in a spontaneously hypertensive rat model in vivo.
Catalogue Number524714
Brand Family Calbiochem®
SynonymsPDE V Inhibitor II
References
ReferencesDaugan, A., et al. 2003. J. Med. Chem. 46, 4533. Daugan, A., et al. 2003. J. Med. Chem. 46, 4525.
Product Information
FormWhite solid
Hill FormulaC₂₄H₂₅N₃O₃
Chemical formulaC₂₄H₂₅N₃O₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetbovine aorta PDEV
Primary Target IC<sub>50</sub>5 nM
Secondary targetIC₅₀ > 10 µM for human recombinant PDE I & III, and for bovine aorta PDE II & IV
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
524714 0

Documentation

Phosphodiesterase V Inhibitor II Certificates of Analysis

TitleLot Number
524714

References

Reference overview
Daugan, A., et al. 2003. J. Med. Chem. 46, 4533. Daugan, A., et al. 2003. J. Med. Chem. 46, 4525.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-August-2008 RFH
SynonymsPDE V Inhibitor II
DescriptionA cell-permeable tetrahydro-b-carboline-hydantoin compound that acts as a potent and highly selective phosphodiesterase V inhibitor (IC50 = 5 nM for bovine aorta PDE V; >10 µM for human recombinant PDE1 and PDE III and bovine aorta PDE II and PDE IV). Reported to increase intracellular cGMP levels in ANF-treated rat smooth muscle cells (RSMC) (EC50 = 1 µM). Also reported to lower blood pressure in a spontaneously hypertensive rat model in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₂₅N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml) or ethanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDaugan, A., et al. 2003. J. Med. Chem. 46, 4533. Daugan, A., et al. 2003. J. Med. Chem. 46, 4525.