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529579 PP1 Analog - CAS 221243-82-9 - Calbiochem

PP1 Analog - CAS 221243-82-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-Na PP1, 1-NA-PP1, 4-Amino-1-tert-butyl-3-(1ʹ-naphthyl)pyrazolo[3,4-d]pyrimidine

Primary Target: I338G mutant v-Src
529579
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
221243-82-9C₁₉H₁₉N₅
Description
OverviewA potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is > 800 times more selective for the I338G mutant v-Src (IC50 = 1.5 nM) compared to wild-type v-Src (IC50 = 1.0 µM). Also inhibits wild-type Fyn (IC50 = 600 nM). Also available in InSolution™ format (Cat. No. 529605).
Catalogue Number529579
Brand Family Calbiochem®
Synonyms1-Na PP1, 1-NA-PP1, 4-Amino-1-tert-butyl-3-(1ʹ-naphthyl)pyrazolo[3,4-d]pyrimidine
References
ReferencesBishop, A.C., et al. 2000. Nature 407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc. 121, 627.
Product Information
CAS number221243-82-9
ATP CompetitiveY
Declaration

Not available for sale in the United States.
FormOff-white solid
Hill FormulaC₁₉H₁₉N₅
Chemical formulaC₁₉H₁₉N₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetI338G mutant v-Src
Primary Target IC<sub>50</sub>1.5 nM against I338G mutant v-Src; 1.0 µM against wild-type v-Src; 600 nM against wild-type Fyn
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
529579 0

Documentation

PP1 Analog - CAS 221243-82-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PP1 Analog - CAS 221243-82-9 - Calbiochem Certificates of Analysis

TitleLot Number
529579

References

Reference overview
Bishop, A.C., et al. 2000. Nature 407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc. 121, 627.

Citations

Title
  • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision16-January-2012 RFH
    Synonyms1-Na PP1, 1-NA-PP1, 4-Amino-1-tert-butyl-3-(1ʹ-naphthyl)pyrazolo[3,4-d]pyrimidine
    DescriptionA potent, reversible, ATP-competitive, cell-permeable and selective inhibitor of Src-family tyrosine kinases that is > 800 times more selective for the I338G mutant v-Src (IC50 = 1.5 nM) compared to wild-type v-Src (IC50 = 1 µM). Also inhibits wild-type Fyn (IC50 = 600 nM). Also available in InSolution™ format (Cat. No. 529605).
    FormOff-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number221243-82-9
    Chemical formulaC₁₉H₁₉N₅
    Structure formulaStructure formula
    Purity≥99% by HPLC
    SolubilityDMSO (10 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
    Toxicity Standard Handling
    ReferencesBishop, A.C., et al. 2000. Nature 407, 395.
    Bishop, A.C., et al. 1999 J. Am. Chem. Soc. 121, 627.
    Citation
  • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
    		•