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532978 PLD2 Inhibitor, ML395 - CAS 1638957-17-1 - Calbiochem

ML395 is a cell permeable, highly potent, selective, and direct allosteric inhibitor of phospholipase D2 (PLD2; IC₅₀ = 360 nM) that exhibits >80-fold selectivity over PLD1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Phosppolipase D2 inhibitor, VU0468809, ML-395

Primary Target: PLD2
532978
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1638957-17-1C₂₆H₂₉N₅O₂

Products

Catalogue NumberPackaging Qty/Pack
5.32978.0001 Glass bottle 10 mg
Description
OverviewA cell permeable, triazaspirone derivative that acts as a highly potent, selective, and direct allosteric inhibitor of phospholipase D2 (PLD2; IC50 = 360 nM in exogenous biochemical assay). Exhibits >80-fold selectivity over phospholipase D1 (PLD1; IC50 = 30 µM). Shown to permeate the blood-brain barrier. Protects A549 cells from multiple strains of influenza virus when cells were pre-treated with this compound. Exhibits excellent DMPK profile (hepatic microsomal clearance = 82.1 ml/min/kg in Sprague-Dawley rats) and conforms to Lipinski's rule and has favorable lipophilicity. Also displays favorable cytochrome P450 profile (CYP3A4 IC50 = 3.9 µM, CYP2D6 IC50 =16.4 µM, CYP1A2 IC50>30 µM, and CYP2C9 IC50>30 µM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number532978
Brand Family Calbiochem®
SynonymsPhosppolipase D2 inhibitor, VU0468809, ML-395
References
ReferencesO'Reilly, M.C., et al. 2014. ChemMedChem 9, 2633.
Product Information
CAS number1638957-17-1
FormOff-white solid
Hill FormulaC₂₆H₂₉N₅O₂
Chemical formulaC₂₆H₂₉N₅O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPLD2
Primary Target IC<sub>50</sub>360 nM
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.32978.0001 04055977281972

Documentation

PLD2 Inhibitor, ML395 - CAS 1638957-17-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
O'Reilly, M.C., et al. 2014. ChemMedChem 9, 2633.

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2015 JSW
SynonymsPhosppolipase D2 inhibitor, VU0468809, ML-395
DescriptionA cell permeable, triazaspirone derivative that acts as a highly potent, selective, and direct allosteric inhibitor of phospholipase D2 (PLD2; IC50 = 360 nM in exogenous biochemical assay). Exhibits >80-fold selectivity over phospholipase D1 (PLD1; IC50 = 30 µM). Shown to permeate the blood-brain barrier. Protects A549 cells from multiple strains of influenza virus when cells were pre-treated with this compound. Exhibits excellent DMPK profile (hepatic microsomal clearance = 82.1 ml/min/kg in Sprague-Dawley rats) and conforms to Lipinski's rule and has favorable lipophilicity. Also displays favorable cytochrome P450 profile (CYP3A4 IC50 = 3.9 µM, CYP2D6 IC50 =16.4 µM, CYP1A2 IC50>30 µM, and CYP2C9 IC50>30 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1638957-17-1
Chemical formulaC₂₆H₂₉N₅O₂
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).
Toxicity Standard Handling
ReferencesO'Reilly, M.C., et al. 2014. ChemMedChem 9, 2633.