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531551 PKR/PERK Activator, DHBDC - CAS 101068-35-3 - Calbiochem

A cell permeable dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IκBα and thereby activates NF-κB pathway.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Protein Kinase R (PKR) Activator, Protein Kinase R Like Kinase (PERK) Activator

Primary Target: PKR and PERK
531551
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
101068-35-3C₁₇H₁₂O₆

Products

Catalogue NumberPackaging Qty/Pack
5.31551.0001 Glass bottle 10 mg
Description
OverviewA cell permeable chromenone derivative that acts as a dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IkBa and thereby activates NF-κB pathway. However, the activation of NF-κB is independent of PKR activity. Induces elF2a phosphorylation and activates its downstream effectors CHOP/GADD153. Does not affect the phosphorylation of Akt, MAP kinase, or 4E-BP1. Inhibits the expression of cyclin D1 and E and blocks the growth of CRL-2813 and MCF-7 cells (IC50 = ~ 10 µM). Also shown to reduce JFH1 hepatitis C virus infectivity (~40% inhibition at 5 µM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531551
Brand Family Calbiochem®
SynonymsProtein Kinase R (PKR) Activator, Protein Kinase R Like Kinase (PERK) Activator
References
ReferencesBai, H., et al. 2013. ChemBioChem 14, 1255.
Product Information
CAS number101068-35-3
FormWhite to pink powder
Hill FormulaC₁₇H₁₂O₆
Chemical formulaC₁₇H₁₂O₆
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKR and PERK
Primary Target IC<sub>50</sub>~ 10 µ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.31551.0001 04055977260373

Documentation

PKR/PERK Activator, DHBDC - CAS 101068-35-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Bai, H., et al. 2013. ChemBioChem 14, 1255.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-February-2024 JSW
SynonymsProtein Kinase R (PKR) Activator, Protein Kinase R Like Kinase (PERK) Activator
DescriptionA cell permeable chromenone derivative that acts as a dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IkBa and thereby activates NF-κB pathway. However, the activation of NF-κB is independent of PKR activity. Induces elF2a phosphorylation and activates its downstream effectors CHOP/GADD153. Does not affect the phosphorylation of Akt, MAP kinase, or 4E-BP1. Inhibits the expression of cyclin D1 and E and blocks the growth of CRL-2813 and MCF-7 cells (IC50 = ~ 10 µM). Also shown to reduce JFH1 hepatitis C virus infectivity (~40% inhibition at 5 µM).
FormWhite to pink powder
Intert gas (Yes/No) Packaged under inert gas
CAS number101068-35-3
Chemical formulaC₁₇H₁₂O₆
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBai, H., et al. 2013. ChemBioChem 14, 1255.