Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

528112 PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

The PI 3-Kγ/CKII Inhibitor, also referenced under CAS 1138220-19-5, controls the biological activity of PI 3-Kγ/CKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII

Primary Target: PI 3-Kγ/CKII
528112
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1138220-19-5C₁₄H₈FNO₄S

Products

Catalogue NumberPackaging Qty/Pack
528112-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
Catalogue Number528112
Brand Family Calbiochem®
Synonyms(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII
References
ReferencesPomel, V., et al. 2006. J. Med. Chem. 49, 3857.
Product Information
CAS number1138220-19-5
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₄H₈FNO₄S
Chemical formulaC₁₄H₈FNO₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPI 3-Kγ/CKII
Primary Target IC<sub>50</sub>20 nM against PI 3-Kγ and CKII
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528112-5MG 04055977270532

Documentation

PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem Certificates of Analysis

TitleLot Number
528112

References

Reference overview
Pomel, V., et al. 2006. J. Med. Chem. 49, 3857.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII
DescriptionA cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1138220-19-5
Chemical formulaC₁₄H₈FNO₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPomel, V., et al. 2006. J. Med. Chem. 49, 3857.