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530647 Orai1/CRAC Blocker, Cpd5J-4 - CAS 827001-82-1 - Calbiochem

A non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T cells

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Orai1 Inhibitor, CRAC Inhibitor, Ca2+ release-activated Ca2+ (CRAC) channel blocker

Primary Target: Orail1
530647
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
827001-82-1C₁₆H₁₂N₂O₃S

Products

Catalogue NumberPackaging Qty/Pack
5.30647.0001 Glass bottle 10 mg
Description
OverviewA non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T cells. Exhibits a strong blocking effect on store-operated Ca2+ entry in HeLa-O+S cells and in Th17 cells. Preferentially reduces Th17 differentiation and ameliorates Th17-mediated autoimmune disease. Blocks the infiltration of T cells into the CNS and reduces the number of IL-17 producing cells. Also shown to reduce the expression of retinoic acid receptor-related orphan receptors a (RORa) and RORgt. Reduces the symptoms and delays the onset of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoproteins 35-55 (MOG35-55) immunized mice (2 mg/kg, i.p.).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530647
Brand Family Calbiochem®
SynonymsOrai1 Inhibitor, CRAC Inhibitor, Ca2+ release-activated Ca2+ (CRAC) channel blocker
References
ReferencesKim, K., et al. 2014. J Immunol. 192, 110.
Product Information
CAS number827001-82-1
FormOff-white powder
Hill FormulaC₁₆H₁₂N₂O₃S
Chemical formulaC₁₆H₁₂N₂O₃S
Quality LevelMQ100
Applications
Biological Information
Primary TargetOrail1
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.30647.0001 04055977260991

Documentation

Orai1/CRAC Blocker, Cpd5J-4 - CAS 827001-82-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Kim, K., et al. 2014. J Immunol. 192, 110.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2014 JSW
SynonymsOrai1 Inhibitor, CRAC Inhibitor, Ca2+ release-activated Ca2+ (CRAC) channel blocker
DescriptionA non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T cells. Exhibits a strong blocking effect on store-operated Ca2+ entry in HeLa-O+S cells and in Th17 cells. Preferentially reduces Th17 differentiation and ameliorates Th17-mediated autoimmune disease. Blocks the infiltration of T cells into the CNS and reduces the number of IL-17 producing cells. Also shown to reduce the expression of retinoic acid receptor-related orphan receptors a (RORa) and RORgt. Reduces the symptoms and delays the onset of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoproteins 35-55 (MOG35-55) immunized mice (2 mg/kg, i.p.).
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number827001-82-1
Chemical formulaC₁₆H₁₂N₂O₃S
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKim, K., et al. 2014. J Immunol. 192, 110.