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496150 Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem

The Omi/HtrA2 Protease Inhibitor, Ucf-101, also referenced under CAS 313649-08-0, controls the biological activity of Omi/HtrA2 Protease. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: High Temperature Requirement A2 Inhibitor I, 5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid

Primary Target: pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2
496150
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
313649-08-0C₂₇H₁₇N₃O₅S
Description
Overview

This product has been discontinued.



A cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 µM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 µM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts.
Catalogue Number496150
Brand Family Calbiochem®
SynonymsHigh Temperature Requirement A2 Inhibitor I, 5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid
References
ReferencesCilenti, L., et al. 2003. J. Biol. Chem. 278, 11489.
Product Information
CAS number313649-08-0
ATP CompetitiveN
FormOrange solid
Hill FormulaC₂₇H₁₇N₃O₅S
Chemical formulaC₂₇H₁₇N₃O₅S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetpro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
496150 0

Documentation

Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem Certificates of Analysis

TitleLot Number
496150

References

Reference overview
Cilenti, L., et al. 2003. J. Biol. Chem. 278, 11489.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
SynonymsHigh Temperature Requirement A2 Inhibitor I, 5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid
DescriptionA cell-permeable, furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease, Omi/HtrA2 (IC50 = 9.5 µM for His-Omi134-458). Reported to inhibit Omi/HtrA2-induced cell death in caspase-9 (-/-) null fibroblasts. Does not significantly inhibit other serine proteases, including kallikrein, trypsin, plasmin, thrombin, and tissue plasminogen activator (t-PA) (IC50 ≥200 µM).
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number313649-08-0
Chemical formulaC₂₇H₁₇N₃O₅S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCilenti, L., et al. 2003. J. Biol. Chem. 278, 11489.