Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

14-578M NEK6 Protein, active, 250 µg

Active, N-terminal His6-tagged, recombinant, human NEK6, amino acids 2 -end, for use in Kinase Assays.

14-578M
250 µg  Also available in 10 μg size (cat#14-578) and in bulk (cat# 14-578-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-578M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionNEK6 Protein, active, 250 µg
OverviewNN-terminal His6-tagged, recombinant, human NEK6, amino acids 2 - end
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal His6-tagged, recombinant, human NEK6, amino acids 2 -end, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM]
Gene Symbol
  • NEK6
  • SID6-1512
Protein TargetNEK6
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyMisc
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9HC98 # Activated during M phase. Required for chromosome segregation at metaphase-anaphase transition and therefore for mitotic progression. Inhibition of activity results in apoptosis.
COFACTOR: Magnesium.
SIZE: 313 amino acids; 35714 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Ubiquitous, with highest expression in heart and skeletal muscle.
PTM: Autophosphorylated.
SIMILARITY: SwissProt: Q9HC98 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain.
Molecular Weight40.5kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of FLAKSFGSPNRAYKK
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-578) and in bulk (cat# 14-578-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-578M 04053252580741

Documentation