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14-700M NEK11 Protein, active, 250 µg

Active, 6His-tagged, recombinant, human full length, NEK11, for use in Kinase Assays.

14-700M
250 µg  Also available in 10 μg size (cat#14-700) and in bulk (cat#14-700-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-700M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionNEK11 Protein, active, 250 µg
Overview6His-tagged, recombinant, human full length, NEK11
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, 6His-tagged, recombinant, human full length, NEK11, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Entrez Gene Number
Entrez Gene SummaryNEK11 belongs to the NIMA family of kinases, which are involved in DNA replication and genotoxic stress responses (Noguchi et al., 2002 [PubMed 12154088]).[supplied by OMIM]
Gene Symbol
  • NEK11
  • FLJ23495
Protein TargetNEK11
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyMisc
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q8NG66 # Possible role in S-phase checkpoint mechanism.
COFACTOR: Manganese or magnesium.
SIZE: 645 amino acids; 74162 Da
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells.
TISSUE SPECIFICITY: Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
DEVELOPMENTAL STAGE: Predominantly expressed at S/G2/M phase.
PTM: Phosphorylated.
SIMILARITY: SwissProt: Q8NG66 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain.
Molecular Weight59.3kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of MBP (Catalog # 13-104)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-700) and in bulk (cat#14-700-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-700M 04053252925382

Documentation

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-700 NEK11 Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases