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The following MAPmates™ should not be plexed together:
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48-602MAG
Buffer Detection Kit for Magnetic Beads
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616382
Sigma-AldrichNα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem
Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
Catalogue Number
616382
Brand Family
Calbiochem®
Synonyms
TLCK
References
References
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721. Kim, H., et al. 1995. J. Immunol.154, 4741. Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230. Biro, A., et al. 1992. Eur. J. Immunol.22, 2547. Bruno, S., et al. 1992. Leukemia6, 1113. Lee, S.F. 1992. Infect. Immun. 60, 4032. Schmidt, H.H., et al. 1992. Mol. Pharmacol.41, 615.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
18-September-2008 JSW
Synonyms
TLCK
Description
Inhibits trypsin-like serine proteases. Inactivates trypsin irreversibly without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Suggesting working concentration is 10-100 µM.
Form
Off-white solid
CAS number
4238-41-9
RTECS
XT5160000
Chemical formula
C₁₄H₂₁ClN₂O₃S . HCl
Structure formula
Purity
≥95% by elemental analysis
Solubility
Aqueous solutions pH <6.0 (1 mg/ml)
Storage
+2°C to +8°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Unstable in solution; reconstitute just prior to use.
Toxicity
Irritant
References
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721. Kim, H., et al. 1995. J. Immunol.154, 4741. Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230. Biro, A., et al. 1992. Eur. J. Immunol.22, 2547. Bruno, S., et al. 1992. Leukemia6, 1113. Lee, S.F. 1992. Infect. Immun. 60, 4032. Schmidt, H.H., et al. 1992. Mol. Pharmacol.41, 615.
