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110115 N-Acetyl-S-geranylgeranyl-L-cysteine

N-Acetyl-S-geranylgeranyl-L-cysteine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AGGC

110115
  
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Overview

Replacement Information
Description
OverviewInhibitor of methylation of geranylgeranylated proteins that exhibits higher affinity (Km = 7 µM) than AFC (Cat. No. 110110) for carboxyl methyltransferase. A potent inhibitor of β2-integrin-induced actin polymerization (IC50 = 45 nM). An effective inhibitor of fMLP-induced superoxide generation (IC50 = 4 µM).
Catalogue Number110115
Brand Family Calbiochem®
SynonymsAGGC
References
ReferencesRosado, J.A., and Sage, S.O. 2000. Biochem. J. 347, 183. Molony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Scheer, A., and Gierschik, P. 1995. Biochemistry 34, 4952. Philips, M.R., et al. 1993. Science 259, 977. Volker, C., et al. 1991. FEBS Lett. 295, 189.
Product Information
FormClear yellow viscous oil
Hill FormulaC₂₅H₄₁NO₃S
Chemical formulaC₂₅H₄₁NO₃S
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetβ2-integrin-induced actin polymerization
Primary Target IC<sub>50</sub>45 nM
Secondary targetKnown to block the fMLP-induced release of superoxides in human neutrophils (IC₅₀ = 4 µM)
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). DMSO solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
110115 0

Documentation

N-Acetyl-S-geranylgeranyl-L-cysteine Certificates of Analysis

TitleLot Number
110115

References

Reference overview
Rosado, J.A., and Sage, S.O. 2000. Biochem. J. 347, 183. Molony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Scheer, A., and Gierschik, P. 1995. Biochemistry 34, 4952. Philips, M.R., et al. 1993. Science 259, 977. Volker, C., et al. 1991. FEBS Lett. 295, 189.