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530310 Mithramycin A - CAS 18378-89-7 - Calbiochem

An antibiotic with anti-tumor properties that binds to G-C rich DNA and displaces Sp1 transcription factor from its sites in the promoters of selected oncogenes, such as c-Myc and c-Src.

Mithramycin A - CAS 18378-89-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Plicamycin, Mithramycin

Primary Target: Sp1 transcription factor
530310
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
18378-89-7C₅₂H₇₆O₂₄
Description
OverviewAn aureolic acid type tricyclic pentaglycoside antibiotics with anti-tumor properties. Binds to G-C rich DNA and displaces Sp1 transcription factor from its sites in the promoters of selected oncogenes, such as c-Myc and c-Src. Mithramycin A-induced inhibition of Sp1 activity has been linked to greater DNA damage and cell death in cells that are homozygous for SNP309. Specifically reduces the levels of MDM2 in human ductal breast epithelial tumor cell line, T47D (5-fold reduction at 200 nM), but does not affect cells that are wild-type for SNP309. Shown to induce myeloid differentiation of leukemic blasts that leads to reduction in the level of expression of c-Myc and c-Abl proto oncogenes that harbor G-C rich promoters. Inhibits Mcl-1 activity and mTOR phosphorylation (Ser2448) in prostate cancer cells without affecting normal human prostate epithelial cells. Shown to reduce expression of endogenous transient receptor potential vanilpod receptor (TRPV1)-like protein in dorsal root ganglionic neurons.
Catalogue Number530310
Brand Family Calbiochem®
SynonymsPlicamycin, Mithramycin
References
ReferencesZavala, K., et al. 2014. Neurosci Lett. 562,in press.
Choi, E. S., et al. 2013. J. Clin. Biochem. Nutr. 53, 89.
Sleiman S. F., et al. 2011. J. Neurosci. 31, 6858.
Bond, G, et al. 2004. Cell. 119, 591.
Blume, S, et al. 1991. J. Clin. Invest. 88, 1613.
Product Information
CAS number18378-89-7
FormYellow powder
Hill FormulaC₅₂H₇₆O₂₄
Chemical formulaC₅₂H₇₆O₂₄
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetSp1 transcription factor
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 62-63

Possible risk of impaired fertility.
Possible risk of harm to the unborn child.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
530310 0

Documentation

Mithramycin A - CAS 18378-89-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Mithramycin A - CAS 18378-89-7 - Calbiochem Certificates of Analysis

TitleLot Number
530310

References

Reference overview
Zavala, K., et al. 2014. Neurosci Lett. 562,in press.
Choi, E. S., et al. 2013. J. Clin. Biochem. Nutr. 53, 89.
Sleiman S. F., et al. 2011. J. Neurosci. 31, 6858.
Bond, G, et al. 2004. Cell. 119, 591.
Blume, S, et al. 1991. J. Clin. Invest. 88, 1613.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-May-2014 JSW
SynonymsPlicamycin, Mithramycin
DescriptionAn aureolic acid type tricyclic pentaglycoside antibiotics with anti-tumor properties. Binds to G-C rich DNA and displaces Sp1 transcription factor from its sites in the promoters of selected oncogenes, such as c-Myc and c-Src. Mithramycin A-induced inhibition of Sp1 activity has been linked to greater DNA damage and cell death in cells that are homozygous for SNP309. Specifically reduces the levels of MDM2 in human ductal breast epithelial tumor cell line, T47D (5-fold reduction at 200 nM), but does not affect cells that are wild-type for SNP309. Shown to induce myeloid differentiation of leukemic blasts that leads to reduction in the level of expression of c-Myc and c-Abl proto oncogenes that harbor G-C rich promoters. Inhibits Mcl-1 activity and mTOR phosphorylation (Ser2448) in prostate cancer cells without affecting normal human prostate epithelial cells. Shown to reduce expression of endogenous transient receptor potential vanilpod receptor (TRPV1)-like protein in dorsal root ganglionic neurons.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number18378-89-7
Chemical formulaC₅₂H₇₆O₂₄
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesZavala, K., et al. 2014. Neurosci Lett. 562,in press.
Choi, E. S., et al. 2013. J. Clin. Biochem. Nutr. 53, 89.
Sleiman S. F., et al. 2011. J. Neurosci. 31, 6858.
Bond, G, et al. 2004. Cell. 119, 591.
Blume, S, et al. 1991. J. Clin. Invest. 88, 1613.