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504633 MTEP Hydrochloride - CAS 1186195-60-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride

Primary Target: mGlu₅ receptors
504633
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1186195-60-7C₁₁H₈N₂SHCl

Products

Catalogue NumberPackaging Qty/Pack
5.04633.0001 Glass bottle 10 mg
Description
OverviewA non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5 nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
Catalogue Number504633
Brand Family Calbiochem®
Synonyms3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride
References
ReferencesCosford, N., et al. 2003. J. Med. Chem. 46, 204.
Varty, B., et al. 2005. Psychopharmacol. 179, 207.
Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
Wang, X., et al. 2013. Addict. Biol. 18, 40.
Product Information
CAS number1186195-60-7
FormCream solid
Hill FormulaC₁₁H₈N₂SHCl
Chemical formulaC₁₁H₈N₂SHCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetmGlu₅ receptors
Primary Target IC<sub>50</sub>5 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.04633.0001 04055977243963

Documentation

MTEP Hydrochloride - CAS 1186195-60-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Cosford, N., et al. 2003. J. Med. Chem. 46, 204.
Varty, B., et al. 2005. Psychopharmacol. 179, 207.
Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
Wang, X., et al. 2013. Addict. Biol. 18, 40.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2013 JSW
Synonyms3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride
DescriptionA non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5 nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
FormCream solid
CAS number1186195-60-7
Chemical formulaC₁₁H₈N₂SHCl
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCosford, N., et al. 2003. J. Med. Chem. 46, 204.
Varty, B., et al. 2005. Psychopharmacol. 179, 207.
Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
Wang, X., et al. 2013. Addict. Biol. 18, 40.