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504685 LY 354740 - CAS 176199-48-7 - Calbiochem

LY 354740 - CAS 176199-48-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad

Primary Target: mGlu2/3 receptors
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
176199-48-7C₈H₁₁NO₄
Description
Overview

This product has been discontinued.



A highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100 µM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep.
Catalogue Number504685
Brand Family Calbiochem®
Synonyms(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad
References
ReferencesSiok, J., et al. 2012. Neuropharmacol. 62, 226.
Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
Pilc, A., 2003. IDrugs. 6, 71.
Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
Monn, J., 1997. J. Med. Chem. 40, 528.
Schoepp, D., 1997. Neuropharmacol. 36, 1.
Bond, A., 1997. Neuroreport. 8, 1463.
Product Information
CAS number176199-48-7
FormWhite solid
Hill FormulaC₈H₁₁NO₄
Chemical formulaC₈H₁₁NO₄
Sold on the basis of peptide contentY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetmGlu2/3 receptors
Purity≥99% by HPLC
Physicochemical Information
Peptide ContentY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
504685 0

Documentation

LY 354740 - CAS 176199-48-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Siok, J., et al. 2012. Neuropharmacol. 62, 226.
Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
Pilc, A., 2003. IDrugs. 6, 71.
Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
Monn, J., 1997. J. Med. Chem. 40, 528.
Schoepp, D., 1997. Neuropharmacol. 36, 1.
Bond, A., 1997. Neuroreport. 8, 1463.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2013 JSW
Synonyms(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad
DescriptionA highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100 µM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep.
FormWhite solid
CAS number176199-48-7
Chemical formulaC₈H₁₁NO₄
Structure formulaStructure formula
Purity≥99% by HPLC
Solubility1N NaOH (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesSiok, J., et al. 2012. Neuropharmacol. 62, 226.
Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
Pilc, A., 2003. IDrugs. 6, 71.
Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
Monn, J., 1997. J. Med. Chem. 40, 528.
Schoepp, D., 1997. Neuropharmacol. 36, 1.
Bond, A., 1997. Neuroreport. 8, 1463.