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482100 L-NIL, Dihydrochloride - Calbiochem

A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase than for the rat brain constitutive enzyme

L-NIL, Dihydrochloride - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-N⁶-(1-Iminoethyl)lysine, DiHCl

Primary Target: iNOS
482100
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₈H₁₇N₃O₂ · 2HCl
Description
Overview

This product has been discontinued.



A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase (IC50 = 3.3 µM) than for the rat brain constitutive enzyme (IC50 = 92 µM). Exhibits about 10-fold greater inhibitory potency than NG-Monomethyl-L-arginine (L-NMMA; Cat. No. 475886) in inhibiting γ-interferon-induced NO2- production (IC50 = 460 nM).
Catalogue Number482100
Brand Family Calbiochem®
SynonymsL-N⁶-(1-Iminoethyl)lysine, DiHCl
References
ReferencesMoore, W.M., et al. 1996. J. Med. Chem. 39, 669.
Connor, J.R., et al. 1995. Eur. J. Pharmacol. 273, 15.
Stenger, S., et al. 1995. Eur. J. Pharmacol. 294, 703.
Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
Stuehr, D.J., and Griffith, O.W. 1992. Adv. Enzymol. 65, 287.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₁₇N₃O₂ · 2HCl
Chemical formulaC₈H₁₇N₃O₂ · 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetiNOS
Primary Target IC<sub>50</sub>3.3 µM against inducible nitric oxide synthase
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
482100 0

Documentation

L-NIL, Dihydrochloride - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

L-NIL, Dihydrochloride - Calbiochem Certificates of Analysis

TitleLot Number
482100

References

Reference overview
Moore, W.M., et al. 1996. J. Med. Chem. 39, 669.
Connor, J.R., et al. 1995. Eur. J. Pharmacol. 273, 15.
Stenger, S., et al. 1995. Eur. J. Pharmacol. 294, 703.
Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
Stuehr, D.J., and Griffith, O.W. 1992. Adv. Enzymol. 65, 287.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-August-2008 RFH
SynonymsL-N⁶-(1-Iminoethyl)lysine, DiHCl
DescriptionA potent and selective inhibitor of inducible nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase (IC50 = 3.3 µM) than for the rat brain constitutive enzyme (IC50 = 92 µM). Exhibits about 10-fold greater inhibitory potency than NG-monomethyl-L-arginine in inhibiting γ-interferon-induced NO2· production (IC50 = 460 nM)
FormWhite solid
Chemical formulaC₈H₁₇N₃O₂ · 2HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (100 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 3 months at 4°C.
Toxicity Irritant
ReferencesMoore, W.M., et al. 1996. J. Med. Chem. 39, 669.
Connor, J.R., et al. 1995. Eur. J. Pharmacol. 273, 15.
Stenger, S., et al. 1995. Eur. J. Pharmacol. 294, 703.
Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
Stuehr, D.J., and Griffith, O.W. 1992. Adv. Enzymol. 65, 287.