420119 Sigma-AldrichJNK Inhibitor II - CAS 129-56-6 - Calbiochem
JNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3).
More>> JNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3). Less<<JNK Inhibitor II - CAS 129-56-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 129-56-6 | C₁₄H₈N₂O |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 420119-25MG | Plastic ampoule | 25 mg | |
| 420119-50MG | Plastic ampoule | 50 mg | |
| 420119-5MG | Plastic ampoule | 5 mg |
| Description | |
|---|---|
| Overview | A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available. |
| Catalogue Number | 420119 |
| Brand Family | Calbiochem® |
| Synonyms | Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II |
| References | |
|---|---|
| References | Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311. Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681. Han, Z., et al. 2001. J. Clin. Invest. 108, 73. |
| Product Information | |
|---|---|
| CAS number | 129-56-6 |
| ATP Competitive | Y |
| Form | Yellowish orange solid |
| Hill Formula | C₁₄H₈N₂O |
| Chemical formula | C₁₄H₈N₂O |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ200 |
| Biological Information | |
|---|---|
| Primary Target | JNK 1, JNK 2, JNK 3 |
| Primary Target IC<sub>50</sub> | 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Safety Information according to GHS | |
|---|---|
| RTECS | CB4585000 |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 420119-25MG | 04055977187977 |
| 420119-50MG | 04055977187991 |
| 420119-5MG | 07790788050092 |