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420119 JNK Inhibitor II - CAS 129-56-6 - Calbiochem

420119
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Overview

Key Spec Table

CAS #Empirical Formula
129-56-6C₁₄H₈N₂O

Products

Catalogue NumberPackaging Qty/Pack
420119-25MG Plastic ampoule 25 mg
420119-50MG Plastic ampoule 50 mg
420119-5MG Plastic ampoule 5 mg
Description
OverviewA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
Catalogue Number420119
Brand Family Calbiochem®
SynonymsAnthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
References
ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
Product Information
CAS number129-56-6
ATP CompetitiveY
FormYellowish orange solid
Hill FormulaC₁₄H₈N₂O
Chemical formulaC₁₄H₈N₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationJNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3).
Biological Information
Primary TargetJNK 1, JNK 2, JNK 3
Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSCB4585000
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
420119-25MG 04055977187977
420119-50MG 04055977187991
420119-5MG 07790788050092