Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

371957 Isogranulatimide - CAS 244148-46-7 - Calbiochem

Isogranulatimide, also referenced under CAS 244148-46-7, modulates the biological activity of Chk1 and GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IGR, Chk2 Inhibitor III, Chk1 Inhibitor III

Primary Target: Chk1
371957
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
244148-46-7C₁₅H₈N₄O₂
Description
OverviewA cell-permeable alkaloid containing indole/maleimide/imidazole skeleton that acts as a potent, reversible and ATP-competitive inhibitor of Chk1 (IC50 = 100 nM) and GSK-3β (IC50 = 500 nM). Inhibits G2 DNA damage checkpoint-associated kinases, Chk2, Cdk1, and DNA-PK only at much higher concentrations (IC50 = 3 µM, 10 µM, and 10 µM, respectively). Only minimally affects the activities of a panel of 11 other kinases tested (IC50 ≥ 40 µM). When used in combination with γ-irradiation, it is also reported to selectively arrest the growth of MCF-7 cells lacking p53 function.
Catalogue Number371957
Brand Family Calbiochem®
SynonymsIGR, Chk2 Inhibitor III, Chk1 Inhibitor III
References
ReferencesJiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221.
Roberge, M., et al. 1998. Cancer Res. 58, 5701.
Product Information
CAS number244148-46-7
ATP CompetitiveY
FormDark red solid
Hill FormulaC₁₅H₈N₄O₂
Chemical formulaC₁₅H₈N₄O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetChk1
Primary Target IC<sub>50</sub>100 nM, 500 nM, against Chk1 and GSK-3β, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
371957 0

Documentation

Isogranulatimide - CAS 244148-46-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Isogranulatimide - CAS 244148-46-7 - Calbiochem Certificates of Analysis

TitleLot Number
371957

References

Reference overview
Jiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221.
Roberge, M., et al. 1998. Cancer Res. 58, 5701.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-December-2009 RFH
SynonymsIGR, Chk2 Inhibitor III, Chk1 Inhibitor III
DescriptionA cell-permeable, potent, reversible, and ATP-competitive inhibitor of Chk1 (IC50 = 100 nM) and GSK-3β (IC50 = 500 nM). Inhibits G2 DNA damage checkpoint-associated kinases, Chk2, Cdk1, and DNA-PK only at much higher concentrations (IC50 = 3 µM, 10 µM, and 10 µM, respectively). Only minimally affects the activities of a panel of 11 other kinases tested (IC50 ≥ 40 µM). When used in combination with γ-irradiation, it is also reported to selectively arrest the growth of MCF-7 cells lacking p53 function.
FormDark red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number244148-46-7
Chemical formulaC₁₅H₈N₄O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesJiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221.
Roberge, M., et al. 1998. Cancer Res. 58, 5701.