407601 Sigma-AldrichInterleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, CAS 509093-47-4, is a cell-permeable, potent and selective inhibitor of IRAK-1 (IC50 = 300 nM) and IRAK-4 (IC50 = 200 nM).
More>> Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, CAS 509093-47-4, is a cell-permeable, potent and selective inhibitor of IRAK-1 (IC50 = 300 nM) and IRAK-4 (IC50 = 200 nM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 509093-47-4 | C₂₀H₂₁N₅O₄ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 407601-5MG | Plastic ampoule | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602). |
| Catalogue Number | 407601 |
| Brand Family | Calbiochem® |
| Synonyms | N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor |
| References | |
|---|---|
| References | Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429. Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842. |
| Product Information | |
|---|---|
| CAS number | 509093-47-4 |
| ATP Competitive | N |
| Form | Yellow crystalline solid |
| Hill Formula | C₂₀H₂₁N₅O₄ |
| Chemical formula | C₂₀H₂₁N₅O₄ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Interleukin-1 receptor-associated kinases |
| Primary Target IC<sub>50</sub> | 300 nM and 200 nM for IRAK-1 and -4 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Safety Information | |
|---|---|
| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
| S Phrase | S: 36 Wear suitable protective clothing. |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 407601-5MG | 04055977211290 |