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407601 Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

407601
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Overview

Key Spec Table

CAS #Empirical Formula
509093-47-4C₂₀H₂₁N₅O₄

Products

Catalogue NumberPackaging Qty/Pack
407601-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).
Catalogue Number407601
Brand Family Calbiochem®
SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor
References
ReferencesBhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
Product Information
CAS number509093-47-4
ATP CompetitiveN
FormYellow crystalline solid
Hill FormulaC₂₀H₂₁N₅O₄
Chemical formulaC₂₀H₂₁N₅O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInterleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, CAS 509093-47-4, is a cell-permeable, potent and selective inhibitor of IRAK-1 (IC50 = 300 nM) and IRAK-4 (IC50 = 200 nM).
Biological Information
Primary TargetInterleukin-1 receptor-associated kinases
Primary Target IC<sub>50</sub>300 nM and 200 nM for IRAK-1 and -4
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
407601-5MG 04055977211290