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504462 InSolution™ Wnt Antagonist I, IWR-1-endo - CAS 1127442-82-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inhibitor of Wnt Response-1, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II, Wnt Pathway Inhibitor I

Primary Target: Axin
504462
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1127442-82-3C₂₅H₁₉N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
5.04462.0001 Glass bottle 5 mg
Description
Catalogue Number504462
Brand Family Calbiochem®
SynonymsInhibitor of Wnt Response-1, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II, Wnt Pathway Inhibitor I
References
ReferencesWang, H., et al. 2011. ACS Chem. Biol. 6, 192.
Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
Huang, S.M., et al. 2009. Nature 461, 614.
Product Information
CAS number1127442-82-3
FormLiquid
FormulationA 25 mM (5 mg/489 µL) solution of Wnt Antagonist I, IWR-1-endo (Cat. No. 681669) in DMSO.
Hill FormulaC₂₅H₁₉N₃O₃
Chemical formulaC₂₅H₁₉N₃O₃
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAxin
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.04462.0001 04055977264104

Documentation

InSolution™ Wnt Antagonist I, IWR-1-endo - CAS 1127442-82-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Wnt Antagonist I, IWR-1-endo - CAS 1127442-82-3 - Calbiochem Certificates of Analysis

TitleLot Number
504462

References

Reference overview
Wang, H., et al. 2011. ACS Chem. Biol. 6, 192.
Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
Huang, S.M., et al. 2009. Nature 461, 614.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-June-2013 JSW
SynonymsInhibitor of Wnt Response-1, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II, Wnt Pathway Inhibitor I
DescriptionA cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 µM). Although both IWR-1-endo and XAV939 (Tankyrase1/2 Inhibitor; Cat. No. 575545) act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.
FormLiquid
FormulationA 25 mM (5 mg/489 µL) solution of Wnt Antagonist I, IWR-1-endo (Cat. No. 681669) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number1127442-82-3
Chemical formulaC₂₅H₁₉N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity Irritant
ReferencesWang, H., et al. 2011. ACS Chem. Biol. 6, 192.
Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
Huang, S.M., et al. 2009. Nature 461, 614.