Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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509612
Sigma-AldrichInSolution™ TAPI-2 - CAS 187034-31-7 - Calbiochem
A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 in H₂O.
More>>A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 in H₂O. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Bennett, T.A., et al. 2000. J. Immunol.164, 4120. Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther.12, 1139. Hooper, N.M., et al. 1997. Biochem. J.321, 265. Parvathy, S., et al. 1997. Biochem. J.327, 37. Arribas, J., et al. 1996. J. Biol. Chem.271, 11376.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
18-April-2014 JSW
Description
A hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM).
Form
Liquid
Formulation
A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.
Intert gas (Yes/No)
Packaged under inert gas
CAS number
187034-31-7
Chemical formula
C₁₉H₃₇N₅O₅
Purity
≥97% by HPLC
Storage
Protect from light ≤ -70°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Bennett, T.A., et al. 2000. J. Immunol.164, 4120. Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther.12, 1139. Hooper, N.M., et al. 1997. Biochem. J.321, 265. Parvathy, S., et al. 1997. Biochem. J.327, 37. Arribas, J., et al. 1996. J. Biol. Chem.271, 11376.
