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555552 InSolution™ Rho Kinase Inhibitor - Calbiochem

The InSolution™ Rho Kinase Inhibitor controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: ROCK
555552
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₆H₂₁N₃O₂S • 2HCl

Products

Catalogue NumberPackaging Qty/Pack
555552-500UG Plastic ampoule 500 μg
Description
Catalogue Number555552
Brand Family Calbiochem®
References
ReferencesIkenoya, M., et al. 2002. J. Neurochem. 81, 9.
Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
Product Information
ATP CompetitiveY
FormLiquid
FormulationA 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
Hill FormulaC₁₆H₂₁N₃O₂S • 2HCl
Chemical formulaC₁₆H₂₁N₃O₂S • 2HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetROCK
Primary Target K<sub>i</sub>1.6 nM against Rho-associated kinase (ROCK)
Purity≥95% by HPLC
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
555552-500UG 04055977268423

Documentation

InSolution™ Rho Kinase Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Rho Kinase Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
555552

References

Reference overview
Ikenoya, M., et al. 2002. J. Neurochem. 81, 9.
Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-September-2008 RFH
DescriptionA cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Inhibits other serine/threonine kinases only at higher concentrations (Ki = 630 nM for PKA, 9.27 µM for PKC, and 10.1 µM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC50 = 2.5 µM). Reported to be a more potent and selective inhibitor than Y-27632 (Cat. No. 688000 & 688001).
FormLiquid
FormulationA 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
Concentration Label Please refer to vial label for lot-specific concentration
Chemical formulaC₁₆H₂₁N₃O₂S • 2HCl
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Harmful
ReferencesIkenoya, M., et al. 2002. J. Neurochem. 81, 9.
Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.