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508315 InSolution™ KN-93 Phosphate in H₂O - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(N-(2-Hydroxyethyl))-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), Phosphate, (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, Phosphate

Primary Target: CaM kinase II
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₂₉ClN₂O₄S • H₃PO₄
Description
Overview

This product has been discontinued.
Catalogue Number508315
Brand Family Calbiochem®
Synonyms2-(N-(2-Hydroxyethyl))-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), Phosphate, (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, Phosphate
References
ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
Product Information
FormLiquid
FormulationA 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.
Hill FormulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
Chemical formulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCaM kinase II
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
508315 0

Documentation

InSolution™ KN-93 Phosphate in H₂O - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
Synonyms2-(N-(2-Hydroxyethyl))-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), Phosphate, (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, Phosphate
DescriptionA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
FormLiquid
FormulationA 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.