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23-060M IKKγ

IKKγ MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays
23-060M
BULK  
Purchase on Sigma-Aldrich

Overview

Key Spec Table

Key ApplicationsSpeciesCascade Component
Enzyme AssaysHuman Substrate
Description
Catalogue Number23-060M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionIKKγ
Alternate Names
  • NF-kappa-B essential modulator. Inhibitor of nuclear factor kappa-B kinase subunit gamma
  • FIP-3
  • NEMO
  • IKKg
Background InformationIKKγ has been shown to play a critical role in NF-κB activation, as the regulatory subunit of IκB kinase, which phosphorylates inhibitors of NF-κB leading to their degradation. Upon cell stimulation, IKKγ can be modified by Lys-63-linked or linear polyubiquitination, both of which are suggested to play key roles in cell signalling, including NF-κB activation. One of the E3 ligases responsible for Lys-63-linked IKKγ polyubiquitination is TRAF6, which participates in several signalling pathways controlling immunity, skin development, osteoclast formation and brain functions.
Product Information
Quality LevelMQ100
Applications
Key Applications
  • Enzyme Assays
Biological Information
Cascade ComponentSubstrate
Entrez Gene Number
Purification MethodPurified using glutathione sepharose.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Packaging Information
Material SizeBULK
Global Trade Item Number
Catalogue Number GTIN
23-060M 04053252959486