505760 Sigma-AldrichHDAC6 Inhibitor II, BRD9757 - CAS 1423058-85-9 - Calbiochem
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1423058-85-8 | C₆H₉NO₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 5.05760.0001 | Glass bottle | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC50 = 30 nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC50 = 0.638, 1.79, 0.694, and 1.09 µM, respectively) and exhibiting much reduced potency against class IIa HDAC4/5/7/9 (IC50 >12.61 µM). Shown to selectively upregulate HDAC6 substrate α-tubulin acetylation in HeLa cells (10 & 30 µM; 24 h) without inducing histone H3 acetylation increase seen with another HDAC6-selective inhibitor Tubastatin A (Cat. No. 382187). Unlike other Zinc-binding group-containing HDAC inhibitors, BRD9757 does not contain an apparent selectivity-imparting capping structure linked to its hydroxamate. |
| Catalogue Number | 505760 |
| Brand Family | Calbiochem® |
| Synonyms | Histone Deacetylase Inhibitor XVI, HDAC Inhibitor XVI, N-Hydroxycyclopent-1-enecarboxamide |
| References | |
|---|---|
| References | Wagner, F.F., et al. 2013. J. Med. Chem. 56, 1772. |
| Product Information | |
|---|---|
| CAS number | 1423058-85-8 |
| Form | Pale orange solid |
| Hill Formula | C₆H₉NO₂ |
| Chemical formula | C₆H₉NO₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | HDAC6 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5.05760.0001 | 04055977243505 |