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361551 GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem

361551
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Overview

Key Spec Table

CAS #Empirical Formula
740841-15-0C₁₈H₁₂BrN₃O₃

Products

Catalogue NumberPackaging Qty/Pack
361551-1MG Plastic ampoule 1 mg
Description
OverviewAn acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 ≥ 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems.
Catalogue Number361551
Brand Family Calbiochem®
Synonyms(2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime
References
ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
Product Information
CAS number740841-15-0
ATP CompetitiveN
FormDark purple solid
Hill FormulaC₁₈H₁₂BrN₃O₃
Chemical formulaC₁₈H₁₂BrN₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetGSK-3α/β
Primary Target IC<sub>50</sub>10 nM against GSK-3α/β
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
361551-1MG 04055977214093