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371758 GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Hydroxycarboxylic Acid Receptor 1 Agonist, 3-Chloro-5-hydroxybenzoic acid

371758
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.



A hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~ 7, 16, 17, 22, and 67 µM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR. Orally active in mice and exhibits NEFAc cholesterol-lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100 mg/kg, p.o.) in vivo.
Catalogue Number371758
Brand Family Calbiochem®
SynonymsHydroxycarboxylic Acid Receptor 1 Agonist, 3-Chloro-5-hydroxybenzoic acid
References
ReferencesDvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.
Product Information
CAS number53984-36-4
FormLight beige solid
Hill FormulaC₇H₅ClO₃
Chemical formulaC₇H₅ClO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGPR81
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
371758 0

Documentation

GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem Certificates of Analysis

TitleLot Number
371758

References

Reference overview
Dvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-May-2013 JSW
SynonymsHydroxycarboxylic Acid Receptor 1 Agonist, 3-Chloro-5-hydroxybenzoic acid
DescriptionA hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~ 7, 16, 17, 22, and 67 µM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR (EC50 >1 mM). Displays good pharmacokinetic characteristics in mice (Cmax/t1/2 = 67.2 µM/1.47 h and 341.9 µM/1.1 h, respectively, upon oral dosing at 30 mg/kg and 100 mg/kg) and exhibits NEFAc- (non-esterified free fatty acid cholesterol) lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100 mg/kg, p.o.) in vivo.
FormLight beige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number53984-36-4
Chemical formulaC₇H₅ClO₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesDvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.